ABSTRACT
BACKGROUND/AIMS: A close relationship has been established between nonalcoholic fatty liver disease (NAFLD) and an elevated risk of coronary heart disease (CHD), but little is known about the association between alcoholic fatty liver disease (AFLD) and CHD risk. The aim of this study was to determine whether AFLD is associated with elevated CHD risk. METHODS: We retrospectively enrolled 10,710 subjects out of 11,469 individuals who visited the Konkuk University Health Care Center for a routine health checkup in 2010. AFLD was diagnosed made when the usual amount of alcohol consumption exceeded 210 g/week in males and 140 g/week in females for the previous 2 years and when hepatic steatosis was detected by liver ultrasonography. The 10-year risk for CHD was estimated using the Framingham Risk Score. RESULTS: Hepatic steatosis was diagnosed in 4,142 of the 10,710 individuals (38.7%); the remainder (i.e., n=6,568) became the control group. The 4,142 individuals with hepatic steatosis were divided into two groups: NAFLD (n=2,953) and AFLD (n=1,189). The risk of CHD was higher in AFLD (6.72+/-0.12) than in the control group (5.50+/-0.04, P<0.001), and comparable to that in NAFLD (7.32+/-0.07, P=0.02). CONCLUSIONS: Individuals with AFLD have an elevated 10-year risk of CHD that is comparable to those with NAFLD. Therefore, AFLD should be considered a significant risk for future CHD, and preventive measures should be considered earlier.
Subject(s)
Adult , Female , Humans , Male , Middle Aged , Age Factors , Alcohol Drinking , Body Mass Index , Coronary Disease/diagnosis , Cross-Sectional Studies , Fatty Liver, Alcoholic/complications , Non-alcoholic Fatty Liver Disease/complications , Republic of Korea/epidemiology , Retrospective Studies , Risk Factors , Sex FactorsABSTRACT
La necrosis avascular (NA) es un problema importante que enfrenta el reumatólogo con mayor frecuencia. Su impacto es mayor en población joven con trascendentes implicaciones sociales y económicas. En la actualidad, quizás la mejor estrategia para disminuir esta patología es la prevención de los factores de riesgo. En este trabajo se presentan los conceptos etiopatogénicos más relevantes para lograr un mejor conocimiento que lleve a la prevención y manejo racional por parte del reumatólogo